Advancing Wound Healing Using Cutaneous Bioelectronic Interfaces for Real-Time Monitoring and Electrical Stimulation

¹Arizona College of Osteopathic Medicine, Glendale, AZ, USA

²California Health Sciences University College of Osteopathic Medicine, USA

³New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA

⁴Department of Dermatology, Northwell Health, New Hyde Park, NY, USA

⁵California Health Sciences University College of Osteopathic Medicine, USA

⁶Philadelphia College of Osteopathic Medicine, PA, USA

⁷School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, USA

⁸College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

*Corresponding author: Kelly Frasier, DO, MS, Department of Dermatology, Northwell Health, New Hyde Park, NY, USA, Phone: 3105956882, Email: [email protected]

Received Date: April 03, 2025

Publication Date: April 26, 2025

Citation: Rizzo D, et al. (2025). Advancing Wound Healing Using Cutaneous Bioelectronic Interfaces for Real-Time Monitoring and Electrical Stimulation. Dermis. 5(2):36.

Copyright: Rizzo D, et al. © (2025).

ABSTRACT

Advances in bioelectronic technologies have opened new frontiers in wound healing, providing innovative solutions for real-time monitoring and therapeutic intervention. Wound healing is a complex physiological process involving hemostasis, inflammation, proliferation, and remodeling, often hindered by chronic conditions, infections, or impaired vascularization. Traditional wound care approaches are limited in their ability to adapt dynamically to the wound environment. This review explores the emerging role of cutaneous bioelectronic interfaces, which integrate real-time monitoring and electrical stimulation, to address these challenges and improve healing outcomes. Bioelectronic interfaces incorporate flexible, biocompatible materials and advanced sensors to track critical wound parameters such as pH, temperature, oxygenation, and infection biomarkers. The real-time feedback enables precision medicine by allowing timely and targeted interventions. In parallel, electrical stimulation has demonstrated significant benefits in enhancing cellular migration, angiogenesis, and tissue regeneration through mechanisms that leverage electrochemical gradients and cellular signaling pathways. The synergy between monitoring and stimulation, supported by closed-loop systems, offers a novel paradigm for adaptive wound care. Despite significant progress, the translation of these systems into clinical practice is hindered by technological, regulatory, and ethical challenges. Issues such as device durability, power management, data privacy, and standardization require further attention. Future directions emphasize the integration of artificial intelligence, advanced biomaterials, and personalized medicine approaches to enhance the utility and accessibility of bioelectronic systems. This review highlights the transformative potential of cutaneous bioelectronic interfaces in wound healing, presenting a pathway toward improved clinical outcomes and setting the stage for interdisciplinary innovation in regenerative medicine.

Keywords: Bioelectronic Technologies, Bioelectronic Medicine, Pathology, Electromagnetic Fields, Cells, Diabetic Wounds