The Role of Platelet-Rich Plasma in the Management of Rosacea and Topical Corticosteroid-Induced Rosacea-Like Dermatitis

Near East University, Faculty of Medicine, Department of Dermatology, Cyprus

*Corresponding author: Serap Maden, Near East University, Faculty of Medicine, Department of Dermatology, Cyprus, Phone: 905391062693, E-mail: [email protected]

Received Date: June 24, 2026

Publication Date: July 22, 2026

Citation: Maden S. (2026). The Role of Platelet-Rich Plasma in the Management of Rosacea and Topical Corticosteroid-Induced Rosacea-Like Dermatitis. Dermis. 6(2):64.

Copyright: Maden S. © (2026).

ABSTRACT

Rosacea and topical corticosteroid-induced rosacea-like dermatitis (TCIRD) are cutaneous conditions that manifest as erythema, telangiectasia, papules and pustules on the face, accompanied by impairment of the skin barrier. Platelet rich plasma (PRP) constitutes a therapeutic procedure that utilizes a centrifuge to separate a concentrated platelets fraction from a low-volume plasma specimen. Use of PRP has expanded beyond wound healing and skin rejuvenation to include the treatment of inflammatory dermatological conditions. This review explores the clinical ramifications of PRP in the treatment of rosacea and TCIRD, conditions marked by inflammation in the skin. The study places particular emphasis on the effect of PRP on the pathogenesis of rosacea. A comprehensive search of the literature was conducted in this review to identify the efficacy of PRP as a therapeutic modality for rosacea and TCIRD. The effectiveness of PRP in the patient's clinic and the pathogenesis of these skin conditions have been thoroughly documented. Treatment outcomes demonstrated efficacy in addressing symptoms related to rosacea and TCIRD, with improvements observed and symptoms alleviated in these cases following PRP intervention. PRP may represent a potential therapeutic option for rosacea and TCIRD; however, further well-designed studies are required to establish its efficacy and optimal treatment protocols.

Keywords: Rosacea, Platelet-Rich Plasma, Intradermal Injection

ABBREVIATION LIST

CCL5: C-C motif chemokine ligand 5
CD34: Cluster of Differentiation 34
DPL: Delicate Pulsed Light
EGF: Epidermal Growth Factor
ETR: Erythematotelangiectatic Rosacea
GAIS: Global Aesthetic Improvement Scale
GFs: Growth Factors
HGF: Hepatocyte Growth Factor
IFN-γ: Interferon Gamma
IL-1: Interleukin-1
MMP: Matrix Metalloproteinase
NF-κB: Nuclear Factor Kappa B
PDGF: Platelet-Derived Growth Factor
PF4: Platelet Factor 4
PPR: Papulopustular Rosacea
PPP: Platelet-Poor Plasma
PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses
PRP: Platelet-Rich Plasma
RGS: Rosacea Grading Scale
ROS: Reactive Oxygen Species
TCIRD: Topical Corticosteroid-induced rosacea-like dermatitis
TGF-β: Transforming Growth Factor Beta
TNF-α: Tumor Necrosis Factor Alpha
UV: Ultraviolet
VEGF: Vascular Endothelial Growth Factor
VISIA: VISIA Complexion Analysis System